These questionnaires track symptoms over time. They do not diagnose any condition. If you are worried about a symptom, or something changes suddenly, contact your doctor. In an emergency, call 911.
About the evidence
The Spider (version 7) is shown and scored exactly as published: each item 0, 0, 25, 50, 75 or 100; question 15 scores 20 per situation; question 25 scores 0, 33.3, 66.6 or 100; each area is the average of its items. In over 11,000 adults, every area correlated moderately to strongly with an established questionnaire for the same symptoms (r = 0.62 to 0.80) and separated people with and without symptomatic hypermobility. Test–retest reliability and the smallest meaningful change have not been published yet, so changes over time should be read as a guide.
COMPASS-31 is shown and scored with the published algorithm: item points summed per area, then weighted (orthostatic intolerance ×4.0, vasomotor ×0.8333, secretomotor ×2.1428571, gastrointestinal ×0.8928571, bladder ×1.111, pupillomotor ×0.333) for a total of 0 to 100. A 2025 Rasch analysis recommends reading the six areas separately rather than relying on the total alone.
References: Simmonds JV, Kazkaz H, Lowe P, Ninis N, Tang E, Ewer E, De Wandele I. The Spider v7 © 2023.
Ewer ER, De Pauw R, Kazkaz H, et al. The Spider: validation in adults. Clin Rheumatol 2024;43:3005–3017.
Ewer E, Kazkaz H, Ninis N, et al. The Spider: initial validation in adolescents. J Pediatr Clin Pract 2024;12:200098.
Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W. COMPASS 31. Mayo Clin Proc 2012;87(12):1196–1201. © Mayo Foundation for Medical Education and Research.
Self-reported symptom burden in POTS: a narrative review. Auton Neurosci 2022.
Treister R, O’Neil K, Downs HM, Oaklander AL. Validation of COMPASS-31 in patients with and without small fiber polyneuropathy. Eur J Neurol 2015;22(7):1124–1130.
Ahn JH, et al. Validation of the Korean COMPASS-31 in Parkinson’s disease. PLoS One 2021.